Assay Detail
Binding
CHEMBL672042
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Compound was evaluated for binding affinity to Dopamine receptor D2 labeled with [3H]spiroperidol (0.5 nM) in rat striatal membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dopamine autoreceptor agonists: computational studies, synthesis and biological investigations
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.73 | 5.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192037 | — | — | 1 | 5.15 |
| CHEMBL34025 | — | — | 1 | 4.30 |
| CHEMBL34022 | — | — | 1 | - |
| CHEMBL433233 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192037 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL34025 | — | IC50 | = | 50400.0 | nM | 4.30 |
| CHEMBL34022 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL433233 | — | IC50 | > | 100000.0 | nM | - |