Assay Detail
Binding
CHEMBL672050
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In vitro binding affinity at Dopamine receptor D2 in rat striata using [3H]domperidone as radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Binding of substituted and conformationally restricted derivatives of N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane at sigma-receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.36 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298758 | — | — | 1 | 5.75 |
| CHEMBL293952 | — | — | 1 | 5.42 |
| CHEMBL296601 | — | — | 1 | 5.24 |
| CHEMBL53170 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298758 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL293952 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL296601 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL53170 | — | IC50 | = | 9320.0 | nM | 5.03 |