Assay Detail
Binding
CHEMBL672089
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Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of a high affinity and stereoselective photoaffinity label for the D-1 dopamine receptor: synthesis and resolution of 7-[125I]iodo-8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro- 1H-3-benzazepine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.33 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 2 | 9.82 |
| CHEMBL356597 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL62 | SCH-23390 | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL356597 | — | Ki | = | 28.0 | nM | 7.55 |