Assay Detail
Binding
CHEMBL672294
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Binding affinity was evaluated against Dopamine receptor D2 on rat striatum using [3H]spiperone as radioligand; ND = Not determined
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization of novel 6-fluorochroman derivatives as potential 5-HT1A receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.72 | 9.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.23 |
| CHEMBL22778 | — | — | 1 | 6.21 |
| CHEMBL95135 | — | — | 1 | - |
| CHEMBL94303 | — | — | 1 | - |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | - |
| CHEMBL313420 | — | — | 1 | - |
| CHEMBL92668 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL22778 | — | Ki | = | 614.0 | nM | 6.21 |
| CHEMBL95135 | — | Ki | - | nM | - | |
| CHEMBL94303 | — | Ki | - | nM | - | |
| CHEMBL2 | PRAZOSIN | Ki | - | nM | - | |
| CHEMBL313420 | — | Ki | - | nM | - | |
| CHEMBL92668 | — | Ki | - | nM | - |