Assay Detail
Binding
CHEMBL672295
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Binding affinity towards dopamine D2 receptors in rat brain synaptosomal preparations
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.61 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10085 | MAZAPERTINE | 2.0 | 1 | 8.66 |
| CHEMBL275045 | — | — | 1 | 7.64 |
| CHEMBL10327 | — | — | 1 | 7.43 |
| CHEMBL10105 | — | — | 1 | 7.34 |
| CHEMBL10417 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10085 | MAZAPERTINE | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL275045 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL10327 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL10105 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL10417 | — | Ki | = | 100.0 | nM | 7.00 |