Assay Detail
Binding
CHEMBL672339
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Binding affinity towards Dopamine receptor D2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.68 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.12 |
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 1 | 7.25 |
| CHEMBL1743798 | — | — | 1 | 6.62 |
| CHEMBL1743804 | — | — | 1 | 6.40 |
| CHEMBL1743803 | — | — | 1 | 6.38 |
| CHEMBL35184 | — | — | 1 | 6.06 |
| CHEMBL34990 | — | — | 1 | 5.99 |
| CHEMBL286849 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL415 | CLOMIPRAMINE | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL1743798 | — | Ki | = | 241.0 | nM | 6.62 |
| CHEMBL1743804 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL1743803 | — | Ki | = | 415.0 | nM | 6.38 |
| CHEMBL35184 | — | Ki | = | 875.0 | nM | 6.06 |
| CHEMBL34990 | — | Ki | = | 1030.0 | nM | 5.99 |
| CHEMBL286849 | — | Ki | = | 2220.0 | nM | 5.65 |