Assay Detail
Binding
CHEMBL672342
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Affinity for Dopamine receptor D2
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Azepinoindole derivatives with high affinity for brain dopamine and serotonin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.88 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.70 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.68 |
| CHEMBL171903 | — | — | 1 | 8.52 |
| CHEMBL176356 | — | — | 1 | 8.17 |
| CHEMBL173315 | — | — | 1 | 8.04 |
| CHEMBL178797 | — | — | 1 | 7.51 |
| CHEMBL176990 | — | — | 1 | 7.47 |
| CHEMBL174949 | — | — | 1 | 7.17 |
| CHEMBL176476 | — | — | 1 | 7.08 |
| CHEMBL366504 | — | — | 1 | 6.43 |
| CHEMBL367981 | — | — | 1 | - |
| CHEMBL176363 | — | — | 1 | - |
| CHEMBL366377 | — | — | 1 | - |
| CHEMBL160430 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL85 | RISPERIDONE | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL171903 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL176356 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL173315 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL178797 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL176990 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL174949 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL176476 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL366504 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL367981 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL176363 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL366377 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL160430 | — | Ki | > | 1000.0 | nM | - |