Assay Detail
Binding
CHEMBL672344
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Binding affinity towards dopamine receptor D2 in rat striatal membranes
30
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT(1A) receptor ligands as conformationally constrained analogues of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 6.27 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.10 |
| CHEMBL2112776 | — | — | 2 | 7.16 |
| CHEMBL444590 | — | — | 1 | 6.93 |
| CHEMBL140406 | — | — | 1 | 6.90 |
| CHEMBL2112773 | — | — | 2 | 6.61 |
| CHEMBL138289 | — | — | 1 | 6.49 |
| CHEMBL138109 | — | — | 1 | 6.42 |
| CHEMBL139505 | — | — | 1 | 6.35 |
| CHEMBL2112774 | — | — | 2 | 6.23 |
| CHEMBL2112779 | — | — | 2 | 6.17 |
| CHEMBL344146 | — | — | 1 | 6.12 |
| CHEMBL2112771 | — | — | 2 | 6.10 |
| CHEMBL2112780 | — | — | 2 | 6.04 |
| CHEMBL140287 | — | — | 1 | 5.91 |
| CHEMBL423181 | — | — | 1 | 5.76 |
| CHEMBL2112778 | — | — | 2 | 5.66 |
| CHEMBL139848 | — | — | 1 | 5.66 |
| CHEMBL138892 | — | — | 1 | 5.53 |
| CHEMBL139146 | — | — | 1 | - |
| CHEMBL344432 | — | — | 1 | - |
| CHEMBL136563 | — | — | 1 | - |
| CHEMBL138899 | — | — | 1 | - |
| CHEMBL138900 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL2112776 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL444590 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL140406 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL2112773 | — | Ki | = | 243.0 | nM | 6.61 |
| CHEMBL138289 | — | Ki | = | 327.0 | nM | 6.49 |
| CHEMBL138109 | — | Ki | = | 378.0 | nM | 6.42 |
| CHEMBL139505 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL2112774 | — | Ki | = | 586.0 | nM | 6.23 |
| CHEMBL2112779 | — | Ki | = | 668.0 | nM | 6.17 |
| CHEMBL344146 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL2112774 | — | Ki | = | 783.0 | nM | 6.11 |
| CHEMBL2112771 | — | Ki | = | 787.0 | nM | 6.10 |
| CHEMBL2112771 | — | Ki | = | 792.0 | nM | 6.10 |
| CHEMBL2112780 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL2112779 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL140287 | — | Ki | = | 1220.0 | nM | 5.91 |
| CHEMBL2112776 | — | Ki | = | 1310.0 | nM | 5.88 |
| CHEMBL423181 | — | Ki | = | 1730.0 | nM | 5.76 |
| CHEMBL2112773 | — | Ki | = | 2120.0 | nM | 5.67 |
| CHEMBL139848 | — | Ki | = | 2190.0 | nM | 5.66 |
| CHEMBL2112778 | — | Ki | = | 2190.0 | nM | 5.66 |
| CHEMBL2112780 | — | Ki | = | 2380.0 | nM | 5.62 |
| CHEMBL138892 | — | Ki | = | 2930.0 | nM | 5.53 |
| CHEMBL344432 | — | Ki | > | 850.0 | nM | - |
| CHEMBL138899 | — | Ki | > | 850.0 | nM | - |
| CHEMBL2112778 | — | Ki | > | 850.0 | nM | - |
| CHEMBL136563 | — | Ki | > | 850.0 | nM | - |
| CHEMBL138900 | — | Ki | > | 850.0 | nM | - |
| CHEMBL139146 | — | Ki | > | 850.0 | nM | - |