Assay Detail
Binding
CHEMBL672353
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Displacement of [3H]YM-09151-2 (60 pm) from dopamine receptor D2 in crude membrane fraction of rat brain corpus striatum
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Stereoisomeric probes for the D1 dopamine receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.95 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35354 | — | — | 1 | 6.47 |
| CHEMBL34095 | — | — | 1 | 6.29 |
| CHEMBL32145 | — | — | 1 | 6.15 |
| CHEMBL284473 | — | — | 1 | 5.85 |
| CHEMBL288090 | — | — | 1 | 5.62 |
| CHEMBL286120 | — | — | 1 | 5.30 |
| CHEMBL286424 | — | — | 1 | - |
| CHEMBL24077 | (R)-SKF-38393 | — | 1 | - |
| CHEMBL286080 | SKF-38393 | — | 1 | - |
| CHEMBL284746 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35354 | — | IC50 | = | 336.0 | nM | 6.47 |
| CHEMBL34095 | — | IC50 | = | 511.0 | nM | 6.29 |
| CHEMBL32145 | — | IC50 | = | 701.0 | nM | 6.15 |
| CHEMBL284473 | — | IC50 | = | 1415.0 | nM | 5.85 |
| CHEMBL288090 | — | IC50 | = | 2425.0 | nM | 5.62 |
| CHEMBL286120 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL286424 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL24077 | (R)-SKF-38393 | IC50 | > | 10000.0 | nM | - |
| CHEMBL286080 | SKF-38393 | IC50 | = | 720000.0 | nM | - |
| CHEMBL284746 | — | IC50 | = | 720000.0 | nM | - |