Assay Detail
Binding
CHEMBL672373
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Evaluated in vivo for the affinity towards Dopamine receptor D2 of rat striatal tissue
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and characterization of iodobenzamide analogues: potential D-2 dopamine receptor imaging agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 8.93 | 10.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267932 | MESPIPERONE | 2.0 | 1 | 10.01 |
| CHEMBL8946 | ETICLOPRIDE | 2.0 | 1 | 9.77 |
| CHEMBL49405 | — | — | 1 | 9.60 |
| CHEMBL267723 | IOLOPRIDE | 2.0 | 1 | 9.37 |
| CHEMBL307023 | IODOSULPIRIDE | — | 1 | 8.82 |
| CHEMBL49897 | IODOPRIDE | — | 1 | 8.52 |
| CHEMBL50154 | IODOAZIDOCLEBOPRIDE | — | 1 | 7.85 |
| CHEMBL8945 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267932 | MESPIPERONE | Kd | = | 0.097 | nM | 10.01 |
| CHEMBL8946 | ETICLOPRIDE | Kd | = | 0.17 | nM | 9.77 |
| CHEMBL49405 | — | Kd | = | 0.25 | nM | 9.60 |
| CHEMBL267723 | IOLOPRIDE | Kd | = | 0.43 | nM | 9.37 |
| CHEMBL307023 | IODOSULPIRIDE | Kd | = | 1.5 | nM | 8.82 |
| CHEMBL49897 | IODOPRIDE | Kd | = | 3.0 | nM | 8.52 |
| CHEMBL50154 | IODOAZIDOCLEBOPRIDE | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL8945 | — | Kd | = | 31.1 | nM | 7.51 |