Assay Detail
Binding
CHEMBL672374
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Ability to bind to Dopamine receptor D2 in vitro in rat sriatal membranes using [3H]spiperone radioligand
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New arylpiperazine 5-HT(1A) receptor ligands containing the pyrimido[2,1-f]purine fragment: synthesis, in vitro, and in vivo pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.43 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191907 | — | — | 1 | 7.03 |
| CHEMBL2112359 | — | — | 1 | 6.78 |
| CHEMBL2112351 | — | — | 1 | 6.74 |
| CHEMBL2112361 | — | — | 1 | 6.65 |
| CHEMBL195849 | — | — | 1 | 6.58 |
| CHEMBL193867 | — | — | 1 | 6.49 |
| CHEMBL195047 | — | — | 1 | 6.38 |
| CHEMBL193595 | — | — | 1 | 6.37 |
| CHEMBL425567 | — | — | 1 | 5.93 |
| CHEMBL2112362 | — | — | 1 | 5.91 |
| CHEMBL2112360 | — | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191907 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL2112359 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL2112351 | — | Ki | = | 182.0 | nM | 6.74 |
| CHEMBL2112361 | — | Ki | = | 226.0 | nM | 6.65 |
| CHEMBL195849 | — | Ki | = | 264.0 | nM | 6.58 |
| CHEMBL193867 | — | Ki | = | 325.0 | nM | 6.49 |
| CHEMBL195047 | — | Ki | = | 414.0 | nM | 6.38 |
| CHEMBL193595 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL425567 | — | Ki | = | 1175.0 | nM | 5.93 |
| CHEMBL2112362 | — | Ki | = | 1245.0 | nM | 5.91 |
| CHEMBL2112360 | — | Ki | = | 1330.0 | nM | 5.88 |