Assay Detail
Binding
CHEMBL672377
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit the [3H]spiperone binding to striatum Dopamine receptor D2 was determined in rat
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.72 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418140 | — | — | 1 | 9.04 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.85 |
| CHEMBL58792 | FLUANISONE | 2.0 | 1 | 8.54 |
| CHEMBL58377 | — | — | 1 | 8.30 |
| CHEMBL60648 | — | — | 1 | 8.14 |
| CHEMBL278044 | — | — | 1 | 8.03 |
| CHEMBL277631 | — | — | 1 | 7.54 |
| CHEMBL267044 | LEVOSULPIRIDE | 2.0 | 1 | 7.41 |
| CHEMBL65107 | — | — | 1 | 6.82 |
| CHEMBL62499 | — | — | 1 | 6.32 |
| CHEMBL59186 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418140 | — | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL58792 | FLUANISONE | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL58377 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL60648 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL278044 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL277631 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL267044 | LEVOSULPIRIDE | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL65107 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL62499 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL59186 | — | Ki | = | 1100.0 | nM | 5.96 |