Assay Detail
Binding
CHEMBL672379
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity of compound for Dopamine receptor D2 in rat striatal membrane determined for antagonist state (low affinity state, D2 Low) with [3H]spiperone (using ketanserin to exclude 5-HT2 receptor binding) in the presence of GTP and sodium
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman D(2) template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.86 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64553 | — | — | 1 | 8.48 |
| CHEMBL420986 | — | — | 1 | 8.32 |
| CHEMBL303556 | — | — | 1 | 8.23 |
| CHEMBL93779 | — | — | 1 | 8.15 |
| CHEMBL60185 | — | — | 1 | 7.45 |
| CHEMBL313851 | — | — | 1 | 7.19 |
| CHEMBL93753 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64553 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL420986 | — | Ki | = | 4.81 | nM | 8.32 |
| CHEMBL303556 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL93779 | — | Ki | = | 7.01 | nM | 8.15 |
| CHEMBL60185 | — | Ki | = | 35.9 | nM | 7.45 |
| CHEMBL313851 | — | Ki | = | 65.1 | nM | 7.19 |
| CHEMBL93753 | — | Ki | = | 67.5 | nM | 7.17 |