Assay Detail
Binding
CHEMBL672658
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Binding affinity at dopamine D2 receptor by [3H]spiperone displacement.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Development of a receptor-interaction model for serotonin 5-HT2 receptor antagonists. Predicting selectivity with respect to dopamine D2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.88 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303313 | — | — | 1 | 8.89 |
| CHEMBL12713 | SERTINDOLE | 4.0 | 1 | 8.39 |
| CHEMBL176643 | — | — | 1 | 8.29 |
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | 7.92 |
| CHEMBL95636 | TEFLUDAZINE | 2.0 | 1 | 7.85 |
| CHEMBL12780 | — | — | 1 | 7.75 |
| CHEMBL422130 | — | — | 1 | 7.43 |
| CHEMBL423009 | — | — | 1 | 7.25 |
| CHEMBL359031 | — | — | 1 | 6.92 |
| CHEMBL516 | CYPROHEPTADINE | 4.0 | 1 | 6.85 |
| CHEMBL422840 | — | — | 1 | 6.80 |
| CHEMBL343034 | — | — | 1 | 6.55 |
| CHEMBL366527 | — | — | 1 | 6.44 |
| CHEMBL144901 | — | — | 1 | 6.43 |
| CHEMBL423024 | — | — | 1 | 6.42 |
| CHEMBL73461 | IRINDALONE | 2.0 | 1 | 6.40 |
| CHEMBL144767 | — | — | 1 | 6.04 |
| CHEMBL440557 | DANITRACEN | 2.0 | 1 | 5.80 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 5.75 |
| CHEMBL143617 | — | — | 1 | 5.20 |
| CHEMBL343444 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303313 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL12713 | SERTINDOLE | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL176643 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL267777 | RITANSERIN | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL95636 | TEFLUDAZINE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL12780 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL422130 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL423009 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL359031 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL516 | CYPROHEPTADINE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL422840 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL343034 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL366527 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL144901 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL423024 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL73461 | IRINDALONE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL144767 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL440557 | DANITRACEN | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL51 | KETANSERIN | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL143617 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL343444 | — | IC50 | = | 6900.0 | nM | 5.16 |