Assay Detail
Binding
CHEMBL672662
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Compound was evaluated for binding affinity to Dopamine receptor D2 labeled with [3H]-SND 919 (0.5 nM) in rat striatal membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dopamine autoreceptor agonists: computational studies, synthesis and biological investigations
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.31 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192037 | — | — | 1 | 7.52 |
| CHEMBL34025 | — | — | 1 | 6.58 |
| CHEMBL34022 | — | — | 1 | 5.57 |
| CHEMBL433233 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192037 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL34025 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL34022 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL433233 | — | IC50 | = | 2800.0 | nM | 5.55 |