Assay Detail
Binding
CHEMBL672750
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Inhibitory binding of [3H]spiperone to Dopamine receptor D2 in membranes from rat corpus striatum
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.52 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.12 |
| CHEMBL415300 | ISOCLOZAPINE | — | 1 | 7.89 |
| CHEMBL72292 | — | — | 1 | 7.51 |
| CHEMBL72794 | — | — | 1 | 7.17 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.48 |
| CHEMBL308090 | — | — | 1 | 5.89 |
| CHEMBL73074 | — | — | 1 | 5.37 |
| CHEMBL70377 | — | — | 1 | 5.19 |
| CHEMBL310712 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL415300 | ISOCLOZAPINE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL72292 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL72794 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL308090 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL73074 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL70377 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL310712 | — | IC50 | = | 8100.0 | nM | 5.09 |