Assay Detail
Functional
CHEMBL672803
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit 50% dopamine receptor D2 in a cell free homogenate of intermediate lobe of pituitary gland
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | Pituitary gland cell |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 34 | 5.84 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87734 | — | — | 1 | 6.72 |
| CHEMBL86325 | — | — | 1 | 6.69 |
| CHEMBL315849 | — | — | 1 | 6.54 |
| CHEMBL431220 | — | — | 1 | 6.45 |
| CHEMBL415080 | — | — | 1 | 6.45 |
| CHEMBL85409 | — | — | 1 | 6.37 |
| CHEMBL85689 | — | — | 1 | 6.12 |
| CHEMBL420972 | — | — | 1 | 6.11 |
| CHEMBL87958 | — | — | 1 | 5.54 |
| CHEMBL83080 | — | — | 1 | 5.54 |
| CHEMBL315468 | — | — | 1 | 5.41 |
| CHEMBL2114209 | — | — | 1 | 5.29 |
| CHEMBL420604 | — | — | 1 | 5.17 |
| CHEMBL314459 | — | — | 1 | 5.15 |
| CHEMBL86931 | — | — | 1 | 4.99 |
| CHEMBL2115213 | — | — | 1 | 4.97 |
| CHEMBL84557 | — | — | 1 | - |
| CHEMBL315535 | — | — | 1 | - |
| CHEMBL24077 | (R)-SKF-38393 | — | 1 | - |
| CHEMBL313304 | — | — | 1 | - |
| CHEMBL87897 | — | — | 1 | - |
| CHEMBL82899 | — | — | 1 | - |
| CHEMBL315005 | — | — | 1 | - |
| CHEMBL315750 | — | — | 1 | - |
| CHEMBL85552 | — | — | 1 | - |
| CHEMBL313530 | — | — | 1 | - |
| CHEMBL86576 | — | — | 1 | - |
| CHEMBL315516 | — | — | 1 | - |
| CHEMBL86669 | — | — | 1 | - |
| CHEMBL419680 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87734 | — | EC50 | = | 192.0 | nM | 6.72 |
| CHEMBL86325 | — | EC50 | = | 204.0 | nM | 6.69 |
| CHEMBL315849 | — | EC50 | = | 286.0 | nM | 6.54 |
| CHEMBL431220 | — | EC50 | = | 359.0 | nM | 6.45 |
| CHEMBL415080 | — | EC50 | = | 358.0 | nM | 6.45 |
| CHEMBL85409 | — | EC50 | = | 427.0 | nM | 6.37 |
| CHEMBL85689 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL420972 | — | EC50 | = | 782.0 | nM | 6.11 |
| CHEMBL87958 | — | EC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL83080 | — | EC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL315468 | — | EC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL2114209 | — | EC50 | = | 5130.0 | nM | 5.29 |
| CHEMBL420604 | — | EC50 | = | 6680.0 | nM | 5.17 |
| CHEMBL314459 | — | EC50 | = | 7030.0 | nM | 5.15 |
| CHEMBL86931 | — | EC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL2115213 | — | EC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL420788 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL87910 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL87172 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL84983 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL419680 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL86669 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL315516 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL86576 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL313530 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL85552 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL315750 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL315005 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL82899 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL87897 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL313304 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL24077 | (R)-SKF-38393 | EC50 | > | 10000.0 | nM | - |
| CHEMBL315535 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL84557 | — | EC50 | > | 10000.0 | nM | - |