Assay Detail
Functional
CHEMBL672804
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Formation of cAMP on Dopamine receptor D2 in vitro in rat intermediate lobe
10
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
(1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.31 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99361 | — | — | 1 | 5.54 |
| CHEMBL542683 | — | — | 1 | 5.54 |
| CHEMBL86931 | — | — | 4 | 5.41 |
| CHEMBL83080 | — | — | 2 | - |
| CHEMBL286080 | SKF-38393 | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99361 | — | EC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL542683 | — | EC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL86931 | — | EC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL86931 | — | EC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL86931 | — | EC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL86931 | — | EC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL83080 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL83080 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL286080 | SKF-38393 | EC50 | > | 10000.0 | nM | - |
| CHEMBL286080 | SKF-38393 | EC50 | > | 10000.0 | nM | - |