Assay Detail
Binding
CHEMBL672946
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.72 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | 7.64 |
| CHEMBL84087 | — | — | 1 | 7.39 |
| CHEMBL81813 | — | — | 1 | 7.34 |
| CHEMBL440134 | — | — | 1 | 7.26 |
| CHEMBL309660 | — | — | 1 | 7.10 |
| CHEMBL83664 | — | — | 1 | 6.96 |
| CHEMBL79598 | — | — | 1 | 6.56 |
| CHEMBL82826 | — | — | 1 | 6.52 |
| CHEMBL418929 | — | — | 1 | 6.42 |
| CHEMBL79927 | — | — | 1 | 6.33 |
| CHEMBL79375 | — | — | 1 | 6.29 |
| CHEMBL84346 | — | — | 1 | 6.22 |
| CHEMBL83787 | — | — | 1 | 6.00 |
| CHEMBL418911 | — | — | 1 | 6.00 |
| CHEMBL83391 | — | — | 1 | - |
| CHEMBL311550 | — | — | 1 | - |
| CHEMBL82167 | — | — | 1 | - |
| CHEMBL442185 | — | — | 1 | - |
| CHEMBL309408 | — | — | 1 | - |
| CHEMBL83894 | FANANSERIN | 2.0 | 1 | - |
| CHEMBL83975 | — | — | 1 | - |
| CHEMBL84465 | — | — | 1 | - |
| CHEMBL83780 | — | — | 1 | - |
| CHEMBL84077 | — | — | 1 | - |
| CHEMBL83035 | — | — | 1 | - |
| CHEMBL312043 | — | — | 1 | - |
| CHEMBL310105 | — | — | 1 | - |
| CHEMBL79420 | — | — | 1 | - |
| CHEMBL415272 | — | — | 1 | - |
| CHEMBL316227 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267777 | RITANSERIN | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL84087 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL81813 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL440134 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL309660 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL83664 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL79598 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL82826 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL418929 | — | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL79927 | — | IC50 | = | 473.0 | nM | 6.33 |
| CHEMBL79375 | — | IC50 | = | 508.0 | nM | 6.29 |
| CHEMBL84346 | — | IC50 | = | 603.0 | nM | 6.22 |
| CHEMBL83787 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL418911 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL82651 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL83391 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL311550 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL82167 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL442185 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL309408 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL83894 | FANANSERIN | IC50 | > | 1000.0 | nM | - |
| CHEMBL83975 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL84465 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL83780 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL84077 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL83035 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL312043 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL310105 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL79420 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL415272 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL316227 | — | IC50 | > | 1000.0 | nM | - |