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Assay Detail

CHEMBL672949

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Binding
Binding affinity was determined against Dopamine receptor D2 using [3H]spiperone
ChEMBL ↗
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(2) dopamine receptor (CHEMBL339) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Piperazinylalkyl heterocycles as potential antipsychotic agents.
Scott MK, Baxter EW, Bennett DJ, Boyd RE, Blum PS, Codd EE, Kukla MJ, Malloy E, Maryanoff BE, Maryanoff CA.
J Med Chem (1995) 38 : 4198 -4210
PubMed 7473547 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 55 7.16 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL54 HALOPERIDOL 4.0 1 9.70
CHEMBL428175 RWJ-25730 — 1 8.92
CHEMBL10085 MAZAPERTINE 2.0 1 8.66
CHEMBL543900 — — 1 8.52
CHEMBL133550 — — 1 8.00
CHEMBL435198 — — 1 8.00
CHEMBL543905 — — 1 8.00
CHEMBL542483 — — 1 7.62
CHEMBL1161061 — — 1 7.58
CHEMBL544373 — — 1 7.55
CHEMBL1161044 — — 1 7.52
CHEMBL538280 — — 1 7.52
CHEMBL1161071 — — 1 7.48
CHEMBL1161074 — — 1 7.30
CHEMBL1161065 — — 1 7.30
CHEMBL42 CLOZAPINE 4.0 1 7.27
CHEMBL552830 — — 1 7.17
CHEMBL1161067 — — 1 7.14
CHEMBL1161063 — — 1 7.09
CHEMBL1161072 — — 1 7.00
CHEMBL1161068 — — 1 7.00
CHEMBL1161057 — — 1 7.00
CHEMBL1161051 — — 1 7.00
CHEMBL1161075 — — 1 7.00
CHEMBL1161055 — — 1 7.00
CHEMBL1161054 — — 1 6.91
CHEMBL1161060 — — 1 6.89
CHEMBL1161095 — — 1 6.78
CHEMBL1161094 — — 1 6.52
CHEMBL1161073 — — 1 6.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL54 HALOPERIDOL Ki = 0.2 nM 9.70
CHEMBL428175 RWJ-25730 Ki = 1.2 nM 8.92
CHEMBL10085 MAZAPERTINE Ki = 2.2 nM 8.66
CHEMBL543900 — Ki = 3.0 nM 8.52
CHEMBL133550 — Ki = 10.0 nM 8.00
CHEMBL435198 — Ki = 10.0 nM 8.00
CHEMBL543905 — Ki = 10.0 nM 8.00
CHEMBL542483 — Ki = 24.0 nM 7.62
CHEMBL1161061 — Ki = 26.0 nM 7.58
CHEMBL544373 — Ki = 28.0 nM 7.55
CHEMBL1161044 — Ki = 30.0 nM 7.52
CHEMBL538280 — Ki = 30.0 nM 7.52
CHEMBL1161071 — Ki = 33.0 nM 7.48
CHEMBL1161065 — Ki = 50.0 nM 7.30
CHEMBL1161074 — Ki = 50.0 nM 7.30
CHEMBL42 CLOZAPINE Ki = 53.6 nM 7.27
CHEMBL552830 — Ki = 68.0 nM 7.17
CHEMBL1161067 — Ki = 72.0 nM 7.14
CHEMBL1161063 — Ki = 81.0 nM 7.09
CHEMBL1161072 — Ki = 100.0 nM 7.00
CHEMBL1161068 — Ki = 100.0 nM 7.00
CHEMBL1161057 — Ki = 100.0 nM 7.00
CHEMBL1161051 — Ki = 100.0 nM 7.00
CHEMBL1161075 — Ki = 100.0 nM 7.00
CHEMBL1161055 — Ki = 100.0 nM 7.00
CHEMBL1161054 — Ki = 122.0 nM 6.91
CHEMBL1161060 — Ki = 130.0 nM 6.89
CHEMBL1161095 — Ki = 167.0 nM 6.78
CHEMBL1161094 — Ki = 300.0 nM 6.52
CHEMBL1161073 — Ki = 300.0 nM 6.52
CHEMBL1161064 — Ki = 300.0 nM 6.52
CHEMBL1161052 — Ki = 300.0 nM 6.52
CHEMBL1161097 — Ki = 333.0 nM 6.48
CHEMBL49 BUSPIRONE Ki = 367.0 nM 6.43
CHEMBL1161069 — Ki = 1000.0 nM 6.00
CHEMBL1161049 — Ki = 1000.0 nM 6.00
CHEMBL1161043 — Ki = 1431.0 nM 5.84
CHEMBL124285 — Ki = 1841.0 nM 5.74
CHEMBL553555 — Ki = 2415.0 nM 5.62
CHEMBL334889 — Ki > 1000.0 nM -
CHEMBL1161053 — Ki > 30.0 nM -
CHEMBL538529 — Ki > 1000.0 nM -
CHEMBL1161062 — Ki > 30.0 nM -
CHEMBL1161045 — Ki > 1000.0 nM -
CHEMBL133880 — Ki > 1000.0 nM -
CHEMBL1161070 — Ki > 1000.0 nM -
CHEMBL1161048 — Ki > 1000.0 nM -
CHEMBL544371 — Ki > 1000.0 nM -
CHEMBL1161050 — Ki > 1000.0 nM -
CHEMBL1161046 — Ki > 1000.0 nM -