Assay Detail
Binding
CHEMBL672952
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Binding affinity was determined by measuring the ability to displace [125I]N-(p-aminophenethyl)-spiroperidol from Dopamine receptor D2 in rat caudate (in vitro)
10
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
(1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.68 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86931 | — | — | 4 | 6.11 |
| CHEMBL99361 | — | — | 1 | 5.34 |
| CHEMBL542683 | — | — | 1 | 5.34 |
| CHEMBL286080 | SKF-38393 | — | 2 | 5.16 |
| CHEMBL83080 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86931 | — | Ki | = | 776.0 | nM | 6.11 |
| CHEMBL86931 | — | Ki | = | 776.0 | nM | 6.11 |
| CHEMBL86931 | — | Ki | = | 807.0 | nM | 6.09 |
| CHEMBL86931 | — | Ki | = | 807.0 | nM | 6.09 |
| CHEMBL99361 | — | Ki | = | 4610.0 | nM | 5.34 |
| CHEMBL542683 | — | Ki | = | 4610.0 | nM | 5.34 |
| CHEMBL286080 | SKF-38393 | Ki | = | 6870.0 | nM | 5.16 |
| CHEMBL286080 | SKF-38393 | Ki | = | 6870.0 | nM | 5.16 |
| CHEMBL83080 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL83080 | — | Ki | > | 10000.0 | nM | - |