Assay Detail
Functional
CHEMBL672967
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested in vitro for dopamine agonist activity in rabbit ear artery after at a dose of 0.3 mg/kg
2
Total Activities
2
Compounds Tested
1
Activity Types
1
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Artery |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
4-(Aminoalkyl)-7-hydroxy-2(3H)-indolones, a novel class of potent presynaptic dopamine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.83 | 8.74 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| DOSE | DOSE | 0.3 | mg.kg-1 | — |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL587 | SKF-89124A | — | 1 | 8.74 |
| CHEMBL368456 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL587 | SKF-89124A | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL368456 | — | EC50 | = | 122.0 | nM | 6.91 |