Assay Detail
Binding
CHEMBL673066
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Binding Affinity was determined against Dopamine receptor D2 in rat striatal membranes using [3H]- spiperone radioligand.
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Binding and preliminary evaluation of 5-hydroxy- and 10-hydroxy-2,3, 12,12a-tetrahydro-1H-[1]benzoxepino[2,3,4-ij]isoquinolines as dopamine receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 5.96 | 8.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.67 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 7.26 |
| CHEMBL155208 | — | — | 1 | 6.56 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 6.14 |
| CHEMBL155352 | — | — | 1 | 6.14 |
| CHEMBL156011 | — | — | 1 | 6.07 |
| CHEMBL157799 | — | — | 1 | 5.91 |
| CHEMBL350471 | — | — | 1 | 5.74 |
| CHEMBL348465 | — | — | 1 | 5.73 |
| CHEMBL422169 | — | — | 1 | 5.66 |
| CHEMBL347243 | — | — | 1 | 5.51 |
| CHEMBL346792 | — | — | 1 | 5.46 |
| CHEMBL439639 | — | — | 1 | 5.19 |
| CHEMBL158067 | — | — | 1 | 5.15 |
| CHEMBL155002 | — | — | 1 | 5.07 |
| CHEMBL154948 | — | — | 1 | 5.03 |
| CHEMBL155066 | — | — | 1 | - |
| CHEMBL436042 | — | — | 1 | - |
| CHEMBL345240 | — | — | 1 | - |
| CHEMBL155351 | — | — | 1 | - |
| CHEMBL154468 | — | — | 1 | - |
| CHEMBL349311 | — | — | 1 | - |
| CHEMBL154015 | — | — | 1 | - |
| CHEMBL154301 | — | — | 1 | - |
| CHEMBL350457 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 2.138 | nM | 8.67 |
| CHEMBL53 | APOMORPHINE | Ki | = | 54.95 | nM | 7.26 |
| CHEMBL155208 | — | Ki | = | 275.42 | nM | 6.56 |
| CHEMBL59 | DOPAMINE | Ki | = | 724.44 | nM | 6.14 |
| CHEMBL155352 | — | Ki | = | 724.44 | nM | 6.14 |
| CHEMBL156011 | — | Ki | = | 851.14 | nM | 6.07 |
| CHEMBL157799 | — | Ki | = | 1230.27 | nM | 5.91 |
| CHEMBL350471 | — | Ki | = | 1819.7 | nM | 5.74 |
| CHEMBL348465 | — | Ki | = | 1862.09 | nM | 5.73 |
| CHEMBL422169 | — | Ki | = | 2187.76 | nM | 5.66 |
| CHEMBL347243 | — | Ki | = | 3090.3 | nM | 5.51 |
| CHEMBL346792 | — | Ki | = | 3467.37 | nM | 5.46 |
| CHEMBL439639 | — | Ki | = | 6456.54 | nM | 5.19 |
| CHEMBL158067 | — | Ki | = | 7079.46 | nM | 5.15 |
| CHEMBL155002 | — | Ki | = | 8511.38 | nM | 5.07 |
| CHEMBL154948 | — | Ki | = | 9332.54 | nM | 5.03 |
| CHEMBL155066 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL436042 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL345240 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL155351 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL154468 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL349311 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL154015 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL154301 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL350457 | — | Ki | < | 10000.0 | nM | - |