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Assay Detail

CHEMBL673068

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards Dopamine receptor D2 in rat striatum using YM-09151-2 as a radioligand
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Striatum
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(2) dopamine receptor (CHEMBL339)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Novel derivatives of 2-pyridinemethylamine as selective, potent, and orally active agonists at 5-HT1A receptors.
Vacher B, Bonnaud B, Funes P, Jubault N, Koek W, Assié MB, Cosi C, Kleven M.
J Med Chem (1999) 42 : 1648 -1660
PubMed 10229633 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 6.10 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL295662 1 6.89
CHEMBL360319 1 6.56
CHEMBL42618 1 6.54
CHEMBL45423 1 6.51
CHEMBL46971 1 6.48
CHEMBL44118 1 6.40
CHEMBL288244 1 6.34
CHEMBL42294 1 6.34
CHEMBL42994 1 6.28
CHEMBL298260 1 6.22
CHEMBL42766 1 6.21
CHEMBL297138 1 6.06
CHEMBL45101 1 6.01
CHEMBL43146 1 5.92
CHEMBL44659 1 5.65
CHEMBL42393 1 5.65
CHEMBL44904 1 5.51
CHEMBL46512 1 5.47
CHEMBL46467 1 5.47
CHEMBL46582 1 5.39

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL295662 Ki = 128.82 nM 6.89
CHEMBL360319 Ki = 275.42 nM 6.56
CHEMBL42618 Ki = 288.4 nM 6.54
CHEMBL45423 Ki = 309.03 nM 6.51
CHEMBL46971 Ki = 331.13 nM 6.48
CHEMBL44118 Ki = 398.11 nM 6.40
CHEMBL288244 Ki = 457.09 nM 6.34
CHEMBL42294 Ki = 457.09 nM 6.34
CHEMBL42994 Ki = 524.81 nM 6.28
CHEMBL298260 Ki = 602.56 nM 6.22
CHEMBL42766 Ki = 616.6 nM 6.21
CHEMBL297138 Ki = 870.96 nM 6.06
CHEMBL45101 Ki = 977.24 nM 6.01
CHEMBL43146 Ki = 1202.26 nM 5.92
CHEMBL44659 Ki = 2238.72 nM 5.65
CHEMBL42393 Ki = 2238.72 nM 5.65
CHEMBL44904 Ki = 3090.3 nM 5.51
CHEMBL46512 Ki = 3388.44 nM 5.47
CHEMBL46467 Ki = 3388.44 nM 5.47
CHEMBL46582 Ki = 4073.8 nM 5.39