Assay Detail
Binding
CHEMBL673094
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In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.37 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.06 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 8.70 |
| CHEMBL304902 | CLOTHIAPINE | 2.0 | 1 | 8.36 |
| CHEMBL415300 | ISOCLOZAPINE | — | 1 | 7.89 |
| CHEMBL67284 | ISOCLOTHIAPINE | — | 1 | 7.52 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.35 |
| CHEMBL63576 | — | — | 1 | 6.93 |
| CHEMBL63756 | FLUPERLAPINE | 2.0 | 1 | 6.88 |
| CHEMBL63590 | — | — | 1 | 6.53 |
| CHEMBL67298 | — | — | 1 | 6.36 |
| CHEMBL63329 | — | — | 1 | 6.28 |
| CHEMBL304493 | — | — | 1 | 5.99 |
| CHEMBL63347 | — | — | 1 | 5.81 |
| CHEMBL67355 | — | — | 1 | 5.71 |
| CHEMBL303173 | — | — | 1 | 5.44 |
| CHEMBL66730 | — | — | 1 | 5.40 |
| CHEMBL65768 | — | — | 1 | 4.62 |
| CHEMBL63390 | — | — | 1 | 4.57 |
| CHEMBL303435 | — | — | 1 | 4.00 |
| CHEMBL292738 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.88 | nM | 9.06 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 2.01 | nM | 8.70 |
| CHEMBL304902 | CLOTHIAPINE | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL415300 | ISOCLOZAPINE | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL67284 | ISOCLOTHIAPINE | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL42 | CLOZAPINE | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL63576 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL63756 | FLUPERLAPINE | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL63590 | — | Ki | = | 297.0 | nM | 6.53 |
| CHEMBL67298 | — | Ki | = | 442.0 | nM | 6.36 |
| CHEMBL63329 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL304493 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL63347 | — | Ki | = | 1550.0 | nM | 5.81 |
| CHEMBL67355 | — | Ki | = | 1966.0 | nM | 5.71 |
| CHEMBL303173 | — | Ki | = | 3652.0 | nM | 5.44 |
| CHEMBL66730 | — | Ki | = | 3970.0 | nM | 5.40 |
| CHEMBL65768 | — | Ki | = | 23900.0 | nM | 4.62 |
| CHEMBL63390 | — | Ki | = | 27100.0 | nM | 4.57 |
| CHEMBL303435 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL292738 | — | Ki | = | 100000.0 | nM | 4.00 |