Assay Detail
Binding
CHEMBL673350
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Tested for the inhibition of [3H]spiperone binding to dopamine D2 receptor
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 8.24 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268974 | — | — | 1 | 9.13 |
| CHEMBL12648 | — | — | 1 | 9.12 |
| CHEMBL273516 | — | — | 1 | 9.00 |
| CHEMBL12507 | — | — | 1 | 8.96 |
| CHEMBL417614 | — | — | 1 | 8.80 |
| CHEMBL12910 | — | — | 1 | 8.72 |
| CHEMBL268970 | — | — | 1 | 8.68 |
| CHEMBL12453 | — | — | 1 | 8.66 |
| CHEMBL13051 | — | — | 1 | 8.66 |
| CHEMBL12186 | — | — | 1 | 8.64 |
| CHEMBL12843 | — | — | 1 | 8.59 |
| CHEMBL267549 | — | — | 1 | 8.47 |
| CHEMBL267304 | — | — | 1 | 8.43 |
| CHEMBL12235 | — | — | 1 | 8.42 |
| CHEMBL12713 | SERTINDOLE | 4.0 | 1 | 8.39 |
| CHEMBL418160 | — | — | 1 | 8.38 |
| CHEMBL430151 | — | — | 1 | 8.35 |
| CHEMBL269679 | — | — | 1 | 8.33 |
| CHEMBL274176 | — | — | 1 | 8.24 |
| CHEMBL275496 | — | — | 1 | 8.19 |
| CHEMBL95636 | TEFLUDAZINE | 2.0 | 1 | 8.00 |
| CHEMBL274861 | — | — | 1 | 7.92 |
| CHEMBL12780 | — | — | 1 | 7.75 |
| CHEMBL275494 | — | — | 1 | 7.68 |
| CHEMBL273235 | — | — | 1 | 7.64 |
| CHEMBL13048 | — | — | 1 | 7.62 |
| CHEMBL274648 | — | — | 1 | 7.11 |
| CHEMBL12848 | — | — | 1 | 7.04 |
| CHEMBL13053 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268974 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL12648 | — | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL273516 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL12507 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL417614 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL12910 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL268970 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL12453 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL13051 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL12186 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL12843 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL267549 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL267304 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL12235 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL12713 | SERTINDOLE | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL418160 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL430151 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL269679 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL274176 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL275496 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL95636 | TEFLUDAZINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL274861 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL12780 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL275494 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL273235 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL13048 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL274648 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL12848 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL13053 | — | IC50 | = | 810.0 | nM | 6.09 |