Assay Detail
Binding
CHEMBL673353
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Binding affinity against Dopamine receptor D2 using [3H]spiperone as radioligand
44
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
N-substituted 1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolines and 3-phenylpiperidines: effects on central dopamine and sigma receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 6.05 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70929 | — | — | 1 | 8.22 |
| CHEMBL67583 | — | — | 3 | 7.60 |
| CHEMBL450863 | — | — | 1 | 7.47 |
| CHEMBL305000 | — | — | 1 | 7.42 |
| CHEMBL66208 | — | — | 1 | 7.36 |
| CHEMBL56519 | — | — | 1 | 7.04 |
| CHEMBL68952 | — | — | 1 | 6.99 |
| CHEMBL305793 | — | — | 1 | 6.96 |
| CHEMBL56618 | — | — | 1 | 6.94 |
| CHEMBL2114053 | — | — | 2 | 6.80 |
| CHEMBL56617 | — | — | 1 | 6.58 |
| CHEMBL48219 | — | — | 1 | 6.56 |
| CHEMBL424223 | — | — | 1 | 6.45 |
| CHEMBL7549 | PRECLAMOL | 2.0 | 1 | 6.38 |
| CHEMBL8268 | — | — | 1 | 6.36 |
| CHEMBL70186 | — | — | 1 | 6.36 |
| CHEMBL67584 | — | — | 2 | 6.14 |
| CHEMBL67329 | — | — | 1 | 6.11 |
| CHEMBL56630 | — | — | 2 | 6.05 |
| CHEMBL67440 | — | — | 1 | 6.00 |
| CHEMBL68855 | — | — | 1 | 5.91 |
| CHEMBL49597 | — | — | 1 | 5.88 |
| CHEMBL2114055 | — | — | 1 | 5.81 |
| CHEMBL7393 | — | — | 1 | 5.77 |
| CHEMBL8033 | — | — | 1 | 5.76 |
| CHEMBL8626 | — | — | 1 | 5.71 |
| CHEMBL45778 | — | — | 1 | 5.57 |
| CHEMBL68432 | — | — | 1 | 5.52 |
| CHEMBL69500 | — | — | 1 | 5.46 |
| CHEMBL47750 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70929 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL67583 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL450863 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL305000 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL66208 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL56519 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL67583 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL68952 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL305793 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL56618 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL2114053 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL56617 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL48219 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL424223 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL7549 | PRECLAMOL | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL70186 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL8268 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL67584 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL67329 | — | IC50 | = | 786.0 | nM | 6.11 |
| CHEMBL56630 | — | IC50 | = | 895.0 | nM | 6.05 |
| CHEMBL67440 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL68855 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL49597 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL2114055 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL7393 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL8033 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL8626 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL2114053 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL45778 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL68432 | — | IC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL69500 | — | IC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL47750 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL68989 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL49617 | — | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL69169 | — | IC50 | = | 5520.0 | nM | 5.26 |
| CHEMBL67583 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL302244 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL68916 | — | IC50 | = | 8055.0 | nM | 5.09 |
| CHEMBL432125 | — | IC50 | = | 12150.0 | nM | 4.92 |
| CHEMBL67584 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL305438 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL56630 | — | IC50 | = | 30400.0 | nM | 4.52 |
| CHEMBL412642 | — | IC50 | = | 61800.0 | nM | 4.21 |
| CHEMBL306162 | — | IC50 | > | 100000.0 | nM | - |