Assay Detail
Binding
CHEMBL673355
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards dopamine receptor D2 in rat striatal membrane using [3H]spiperone
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Dopamine autoreceptor agonists as potential antipsychotics. 3.6-Propyl-4,5,5a,6,7,8-hexahydrothiazolo[4,5-f]quinolin-2-amine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.71 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93428 | — | — | 1 | 6.24 |
| CHEMBL150550 | — | — | 2 | 6.07 |
| CHEMBL93972 | — | — | 1 | 5.95 |
| CHEMBL328548 | — | — | 1 | 5.91 |
| CHEMBL91453 | — | — | 1 | 5.66 |
| CHEMBL276500 | — | — | 1 | 5.64 |
| CHEMBL329444 | — | — | 1 | 5.46 |
| CHEMBL92784 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93428 | — | IC50 | = | 574.0 | nM | 6.24 |
| CHEMBL150550 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL93972 | — | IC50 | = | 1129.0 | nM | 5.95 |
| CHEMBL328548 | — | IC50 | = | 1235.0 | nM | 5.91 |
| CHEMBL91453 | — | IC50 | = | 2197.0 | nM | 5.66 |
| CHEMBL150550 | — | IC50 | = | 2243.0 | nM | 5.65 |
| CHEMBL276500 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL329444 | — | IC50 | = | 3428.0 | nM | 5.46 |
| CHEMBL92784 | — | IC50 | = | 15550.0 | nM | 4.81 |