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Assay Detail

CHEMBL673358

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Binding
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes
ChEMBL ↗
48
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Subcellular Membrane
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(2) dopamine receptor (CHEMBL339) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Stereospecific and selective 5-HT2 antagonism in a series of 5-substituted trans-1-piperazino-3-phenylindans.
Bøgesø KP, Arnt J, Hyttel J, Pedersen H.
J Med Chem (1993) 36 : 2761 -2770
PubMed 8410990 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 48 6.46 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL267777 RITANSERIN 2.0 1 7.92
CHEMBL422067 — — 1 7.70
CHEMBL2112372 — — 2 7.48
CHEMBL1788129 — — 1 7.34
CHEMBL1744123 — — 1 7.19
CHEMBL1744107 — — 1 7.17
CHEMBL1788128 — — 1 7.03
CHEMBL1744114 — — 2 7.03
CHEMBL1744126 — — 1 7.03
CHEMBL1744124 — — 1 6.96
CHEMBL1204307 — — 2 6.85
CHEMBL1744125 — — 1 6.80
CHEMBL1744109 — — 1 6.72
CHEMBL1744121 — — 3 6.70
CHEMBL92896 — — 1 6.66
CHEMBL1744111 — — 1 6.66
CHEMBL1744112 — — 1 6.64
CHEMBL1744122 — — 1 6.62
CHEMBL1744120 — — 1 6.58
CHEMBL1744105 — — 1 6.55
CHEMBL1744113 — — 2 6.55
CHEMBL1744127 — — 1 6.52
CHEMBL1744128 — — 1 6.50
CHEMBL1204306 — — 2 6.48
CHEMBL96571 — — 1 6.44
CHEMBL2111567 — — 3 6.43
CHEMBL73461 IRINDALONE 2.0 1 6.40
CHEMBL1744108 — — 1 6.35
CHEMBL1744115 — — 1 6.35
CHEMBL1744106 — — 1 6.31

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL267777 RITANSERIN IC50 = 12.0 nM 7.92
CHEMBL422067 — IC50 = 20.0 nM 7.70
CHEMBL2112372 — IC50 = 33.0 nM 7.48
CHEMBL1788129 — IC50 = 46.0 nM 7.34
CHEMBL1744123 — IC50 = 65.0 nM 7.19
CHEMBL1744107 — IC50 = 67.0 nM 7.17
CHEMBL1788128 — IC50 = 93.0 nM 7.03
CHEMBL1744114 — IC50 = 94.0 nM 7.03
CHEMBL1744126 — IC50 = 93.0 nM 7.03
CHEMBL1744124 — IC50 = 110.0 nM 6.96
CHEMBL1204307 — IC50 = 140.0 nM 6.85
CHEMBL1744125 — IC50 = 160.0 nM 6.80
CHEMBL1744109 — IC50 = 190.0 nM 6.72
CHEMBL1744121 — IC50 = 200.0 nM 6.70
CHEMBL1744111 — IC50 = 220.0 nM 6.66
CHEMBL92896 — IC50 = 220.0 nM 6.66
CHEMBL1744112 — IC50 = 230.0 nM 6.64
CHEMBL1744122 — IC50 = 240.0 nM 6.62
CHEMBL1744120 — IC50 = 260.0 nM 6.58
CHEMBL1744113 — IC50 = 280.0 nM 6.55
CHEMBL1744121 — IC50 = 280.0 nM 6.55
CHEMBL1744105 — IC50 = 280.0 nM 6.55
CHEMBL1744127 — IC50 = 300.0 nM 6.52
CHEMBL1744128 — IC50 = 320.0 nM 6.50
CHEMBL1204306 — IC50 = 330.0 nM 6.48
CHEMBL96571 — IC50 = 360.0 nM 6.44
CHEMBL2111567 — IC50 = 370.0 nM 6.43
CHEMBL73461 IRINDALONE IC50 = 400.0 nM 6.40
CHEMBL1744108 — IC50 = 450.0 nM 6.35
CHEMBL1744115 — IC50 = 450.0 nM 6.35
CHEMBL2112372 — IC50 = 490.0 nM 6.31
CHEMBL1744106 — IC50 = 490.0 nM 6.31
CHEMBL2447982 — IC50 = 500.0 nM 6.30
CHEMBL1744117 — IC50 = 510.0 nM 6.29
CHEMBL2447981 — IC50 = 550.0 nM 6.26
CHEMBL92408 — IC50 = 720.0 nM 6.14
CHEMBL1744119 — IC50 = 750.0 nM 6.12
CHEMBL1744110 — IC50 = 920.0 nM 6.04
CHEMBL1744118 — IC50 = 1100.0 nM 5.96
CHEMBL320684 — IC50 = 1100.0 nM 5.96
CHEMBL1744121 — IC50 = 1300.0 nM 5.89
CHEMBL1744116 — IC50 = 1300.0 nM 5.89
CHEMBL1744114 — IC50 = 1700.0 nM 5.77
CHEMBL2111567 — IC50 = 2200.0 nM 5.66
CHEMBL1204307 — IC50 = 2900.0 nM 5.54
CHEMBL1744113 — IC50 = 4000.0 nM 5.40
CHEMBL2111567 — IC50 = 6300.0 nM 5.20
CHEMBL1204306 — IC50 = 22000.0 nM 4.66