Assay Detail
Binding
CHEMBL673359
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Tested in vitro for inhibition of [3H]spiperone binding to dopamine receptor D2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conformationally restricted analogues of remoxipride as potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.07 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8946 | ETICLOPRIDE | 2.0 | 1 | 9.04 |
| CHEMBL283099 | — | — | 1 | 7.92 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 6.68 |
| CHEMBL2111762 | — | — | 1 | 5.89 |
| CHEMBL22242 | REMOXIPRIDE | 4.0 | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8946 | ETICLOPRIDE | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL283099 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL26 | SULPIRIDE | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2111762 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL22242 | REMOXIPRIDE | IC50 | = | 1570.0 | nM | 5.80 |