Assay Detail
Binding
CHEMBL673372
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In vitro binding affinity towards rat Dopamine receptor D2 by [3H]spiperone displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Aporphines as antagonists of dopamine D-1 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.13 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 7.68 |
| CHEMBL119455 | — | — | 1 | 7.24 |
| CHEMBL155731 | QUINELORANE | 2.0 | 1 | 6.82 |
| CHEMBL155833 | — | — | 1 | 6.35 |
| CHEMBL153960 | — | — | 1 | 6.30 |
| CHEMBL155884 | — | — | 1 | 6.18 |
| CHEMBL416288 | (S)APOMORPHINE | — | 1 | 6.17 |
| CHEMBL345907 | — | — | 1 | 6.09 |
| CHEMBL155246 | — | — | 1 | 6.08 |
| CHEMBL154709 | APOCIDEINE | — | 1 | 5.68 |
| CHEMBL117841 | — | — | 1 | 5.67 |
| CHEMBL157879 | — | — | 1 | 5.65 |
| CHEMBL154989 | — | — | 1 | 5.59 |
| CHEMBL345822 | — | — | 1 | 5.53 |
| CHEMBL157912 | (S)-BULBOCAPNINE | — | 1 | 4.85 |
| CHEMBL157735 | — | — | 1 | - |
| CHEMBL62 | SCH-23390 | — | 1 | - |
| CHEMBL346017 | — | — | 1 | - |
| CHEMBL155883 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL119455 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL155731 | QUINELORANE | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL155833 | — | IC50 | = | 449.0 | nM | 6.35 |
| CHEMBL153960 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL155884 | — | IC50 | = | 664.0 | nM | 6.18 |
| CHEMBL416288 | (S)APOMORPHINE | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL345907 | — | IC50 | = | 803.0 | nM | 6.09 |
| CHEMBL155246 | — | IC50 | = | 829.0 | nM | 6.08 |
| CHEMBL154709 | APOCIDEINE | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL117841 | — | IC50 | = | 2162.0 | nM | 5.67 |
| CHEMBL157879 | — | IC50 | = | 2242.0 | nM | 5.65 |
| CHEMBL154989 | — | IC50 | = | 2579.0 | nM | 5.59 |
| CHEMBL345822 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL157912 | (S)-BULBOCAPNINE | IC50 | = | 14047.0 | nM | 4.85 |
| CHEMBL157735 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL62 | SCH-23390 | IC50 | > | 10000.0 | nM | - |
| CHEMBL346017 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL155883 | — | IC50 | > | 1000.0 | nM | - |