Assay Detail
Binding
CHEMBL673374
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In vitro binding affinity was measured by displacement of [3H]- raclopride from D2 receptor isolated from the striata of male Dawley rats
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Cyclic benzamides as mixed dopamine D2/serotonin 5-HT2 receptor antagonists: potential atypical antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.49 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83625 | — | — | 2 | 8.80 |
| CHEMBL83195 | — | — | 1 | 8.30 |
| CHEMBL315925 | — | — | 1 | 8.28 |
| CHEMBL86013 | — | — | 1 | 8.24 |
| CHEMBL87294 | — | — | 1 | 7.96 |
| CHEMBL314370 | — | — | 1 | 7.77 |
| CHEMBL83510 | — | — | 1 | 7.64 |
| CHEMBL314043 | — | — | 1 | 7.57 |
| CHEMBL85647 | — | — | 1 | 7.50 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.40 |
| CHEMBL41626 | — | — | 1 | 7.37 |
| CHEMBL290937 | — | — | 1 | 7.31 |
| CHEMBL83454 | — | — | 1 | 7.03 |
| CHEMBL85137 | — | — | 1 | 6.66 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.54 |
| CHEMBL3144650 | — | — | 1 | 6.30 |
| CHEMBL314684 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83625 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL83195 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL315925 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL86013 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL83625 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL87294 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL314370 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL83510 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL314043 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL85647 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL41626 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL290937 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL83454 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL85137 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3144650 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL314684 | — | IC50 | = | 600.0 | nM | 6.22 |