Assay Detail
Binding
CHEMBL673581
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity against cloned mammalian Dopamine receptor D2 expressed in CHO cells using [3H]U-86170 as radioligand
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 2. Effects of 8-amino nitrogen substitution on serotonin receptor binding and pharmacology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.34 | 8.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72285 | — | — | 1 | 8.26 |
| CHEMBL1744041 | — | — | 1 | 8.24 |
| CHEMBL1788197 | — | — | 1 | 8.24 |
| CHEMBL1744040 | — | — | 1 | 7.89 |
| CHEMBL70680 | — | — | 1 | 7.89 |
| CHEMBL305837 | — | — | 1 | 7.85 |
| CHEMBL71625 | — | — | 1 | 7.77 |
| CHEMBL72062 | — | — | 1 | 7.60 |
| CHEMBL303921 | — | — | 1 | 7.55 |
| CHEMBL1744039 | — | — | 1 | 7.55 |
| CHEMBL304426 | — | — | 1 | 7.40 |
| CHEMBL304984 | — | — | 1 | 7.23 |
| CHEMBL312525 | — | — | 1 | 7.22 |
| CHEMBL304767 | — | — | 1 | 7.21 |
| CHEMBL1788198 | — | — | 1 | 7.21 |
| CHEMBL420191 | — | — | 1 | 7.05 |
| CHEMBL423127 | — | — | 1 | 6.87 |
| CHEMBL71469 | — | — | 1 | 6.82 |
| CHEMBL71640 | — | — | 1 | 6.64 |
| CHEMBL1788196 | — | — | 1 | 6.60 |
| CHEMBL307786 | — | — | 1 | 6.37 |
| CHEMBL2112317 | — | — | 1 | 6.07 |
| CHEMBL308934 | — | — | 1 | - |
| CHEMBL70970 | — | — | 1 | - |
| CHEMBL306198 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72285 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL1744041 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL1788197 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL1744040 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL70680 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL305837 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL71625 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL72062 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL303921 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL1744039 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL304426 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL304984 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL312525 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL304767 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL1788198 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL420191 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL423127 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL71469 | — | Ki | = | 151.0 | nM | 6.82 |
| CHEMBL71640 | — | Ki | = | 228.0 | nM | 6.64 |
| CHEMBL1788196 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL307786 | — | Ki | = | 423.0 | nM | 6.37 |
| CHEMBL2112317 | — | Ki | = | 859.0 | nM | 6.07 |
| CHEMBL308934 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL70970 | — | Ki | - | nM | - | |
| CHEMBL306198 | — | Ki | > | 1000.0 | nM | - |