Assay Detail
Binding
CHEMBL673588
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In vitro binding affinity at Dopamine receptor D2 in rat striatum by [3H]spiroperidol displacement.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4-(tetralin-1-yl)- and 4-(naphthalen-1-yl)alkyl derivatives of 1-cyclohexylpiperazine as sigma receptor ligands with agonist sigma2 activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.77 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75444 | — | — | 1 | 6.32 |
| CHEMBL53325 | — | — | 1 | 6.22 |
| CHEMBL309064 | — | — | 1 | 5.94 |
| CHEMBL74858 | — | — | 1 | 5.79 |
| CHEMBL306365 | — | — | 1 | 5.61 |
| CHEMBL74811 | — | — | 1 | 5.46 |
| CHEMBL77220 | — | — | 1 | 5.43 |
| CHEMBL75878 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75444 | — | Ki | = | 479.0 | nM | 6.32 |
| CHEMBL53325 | — | Ki | = | 604.0 | nM | 6.22 |
| CHEMBL309064 | — | Ki | = | 1160.0 | nM | 5.94 |
| CHEMBL74858 | — | Ki | = | 1620.0 | nM | 5.79 |
| CHEMBL306365 | — | Ki | = | 2450.0 | nM | 5.61 |
| CHEMBL74811 | — | Ki | = | 3480.0 | nM | 5.46 |
| CHEMBL77220 | — | Ki | = | 3670.0 | nM | 5.43 |
| CHEMBL75878 | — | Ki | = | 4260.0 | nM | 5.37 |