Assay Detail
Binding
CHEMBL673592
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Inhibition of [125I]- NCQ 298 binding to D2 receptor of rat striatal tissue
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 9.97 | 10.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1169525 | — | — | 1 | 10.77 |
| CHEMBL2112608 | — | — | 1 | 10.70 |
| CHEMBL2112607 | — | — | 1 | 10.55 |
| CHEMBL122445 | — | — | 1 | 10.48 |
| CHEMBL122533 | — | — | 1 | 10.44 |
| CHEMBL2112605 | — | — | 1 | 10.42 |
| CHEMBL124612 | — | — | 1 | 10.15 |
| CHEMBL75842 | — | — | 1 | 9.51 |
| CHEMBL340471 | — | — | 1 | 9.42 |
| CHEMBL123282 | — | — | 1 | 9.20 |
| CHEMBL125237 | — | — | 1 | 9.02 |
| CHEMBL325109 | CLEBOPRIDE | 2.0 | 1 | 8.95 |
| CHEMBL3084912 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1169525 | — | Ki | = | 0.017 | nM | 10.77 |
| CHEMBL2112608 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL2112607 | — | Ki | = | 0.028 | nM | 10.55 |
| CHEMBL122445 | — | Ki | = | 0.033 | nM | 10.48 |
| CHEMBL122533 | — | Ki | = | 0.036 | nM | 10.44 |
| CHEMBL2112605 | — | Ki | = | 0.038 | nM | 10.42 |
| CHEMBL124612 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL75842 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL340471 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL123282 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL125237 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL325109 | CLEBOPRIDE | Ki | = | 1.13 | nM | 8.95 |
| CHEMBL3084912 | — | Ki | > | 10.0 | nM | - |