Assay Detail
Binding
CHEMBL673629
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Binding affinity towards Dopamine receptor D2 by displacing [3H]spiperone
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 10.05 | 10.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135722 | — | — | 1 | 10.33 |
| CHEMBL136942 | — | — | 1 | 10.24 |
| CHEMBL135500 | — | — | 1 | 10.20 |
| CHEMBL134545 | — | — | 1 | 10.17 |
| CHEMBL335606 | — | — | 1 | 10.06 |
| CHEMBL267932 | MESPIPERONE | 2.0 | 1 | 9.93 |
| CHEMBL337181 | — | — | 1 | 9.92 |
| CHEMBL135860 | — | — | 1 | 9.92 |
| CHEMBL335714 | — | — | 1 | 9.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135722 | — | Ki | = | 0.047 | nM | 10.33 |
| CHEMBL136942 | — | Ki | = | 0.057 | nM | 10.24 |
| CHEMBL135500 | — | Ki | = | 0.063 | nM | 10.20 |
| CHEMBL134545 | — | Ki | = | 0.067 | nM | 10.17 |
| CHEMBL335606 | — | Ki | = | 0.087 | nM | 10.06 |
| CHEMBL267932 | MESPIPERONE | Ki | = | 0.118 | nM | 9.93 |
| CHEMBL337181 | — | Ki | = | 0.119 | nM | 9.92 |
| CHEMBL135860 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL335714 | — | Ki | = | 0.213 | nM | 9.67 |