Assay Detail
Binding
CHEMBL673630
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Displacement of [3H]spiperone from dopamine receptor D2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 10.40 | 10.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134400 | — | — | 1 | 10.64 |
| CHEMBL137648 | — | — | 1 | 10.64 |
| CHEMBL135917 | — | — | 1 | 10.54 |
| CHEMBL135832 | — | — | 1 | 10.48 |
| CHEMBL337149 | — | — | 1 | 10.46 |
| CHEMBL136852 | — | — | 1 | 10.44 |
| CHEMBL334349 | — | — | 1 | 10.41 |
| CHEMBL137309 | — | — | 1 | 10.37 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 10.24 |
| CHEMBL135316 | — | — | 1 | 10.21 |
| CHEMBL344399 | — | — | 1 | 10.20 |
| CHEMBL538404 | — | — | 1 | 10.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134400 | — | Ki | = | 0.023 | nM | 10.64 |
| CHEMBL137648 | — | Ki | = | 0.023 | nM | 10.64 |
| CHEMBL135917 | — | Ki | = | 0.029 | nM | 10.54 |
| CHEMBL135832 | — | Ki | = | 0.033 | nM | 10.48 |
| CHEMBL337149 | — | Ki | = | 0.035 | nM | 10.46 |
| CHEMBL136852 | — | Ki | = | 0.036 | nM | 10.44 |
| CHEMBL334349 | — | Ki | = | 0.039 | nM | 10.41 |
| CHEMBL137309 | — | Ki | = | 0.043 | nM | 10.37 |
| CHEMBL267930 | SPIPERONE | Ki | = | 0.058 | nM | 10.24 |
| CHEMBL135316 | — | Ki | = | 0.062 | nM | 10.21 |
| CHEMBL344399 | — | Ki | = | 0.063 | nM | 10.20 |
| CHEMBL538404 | — | Ki | = | 0.069 | nM | 10.16 |