Assay Detail
Binding
CHEMBL674020
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of phosphorylation of a polyglutamic acid/tyrosine random copolymer by EGFR enzyme prepared from human A431 carcinoma cell vesicles by immunoaffinity chromatography
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 8.71 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417478 | — | — | 1 | 9.80 |
| CHEMBL31815 | — | — | 1 | 9.38 |
| CHEMBL280757 | — | — | 1 | 9.16 |
| CHEMBL285063 | — | — | 1 | 9.15 |
| CHEMBL28418 | — | — | 1 | 9.12 |
| CHEMBL31373 | — | — | 1 | 9.12 |
| CHEMBL31326 | — | — | 1 | 9.11 |
| CHEMBL31816 | — | — | 1 | 9.02 |
| CHEMBL31570 | — | — | 1 | 9.01 |
| CHEMBL31965 | CANERTINIB | 3.0 | 1 | 8.82 |
| CHEMBL27688 | — | — | 1 | 8.82 |
| CHEMBL31656 | — | — | 1 | 8.82 |
| CHEMBL32079 | — | — | 1 | 8.77 |
| CHEMBL32844 | — | — | 1 | 8.77 |
| CHEMBL27685 | — | — | 1 | 8.74 |
| CHEMBL31622 | — | — | 1 | 8.70 |
| CHEMBL281543 | — | — | 1 | 8.57 |
| CHEMBL286343 | — | — | 1 | 8.52 |
| CHEMBL31419 | — | — | 1 | 8.44 |
| CHEMBL31588 | — | — | 1 | 8.41 |
| CHEMBL284326 | — | — | 1 | 8.18 |
| CHEMBL31630 | — | — | 1 | 7.70 |
| CHEMBL31369 | — | — | 1 | 7.57 |
| CHEMBL283201 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417478 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL31815 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL280757 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL285063 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL28418 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL31373 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL31326 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL31816 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL31570 | — | IC50 | = | 0.97 | nM | 9.01 |
| CHEMBL31965 | CANERTINIB | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL27688 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL31656 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL32079 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL32844 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL27685 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL31622 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL281543 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL286343 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL31419 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL31588 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL284326 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL31630 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL31369 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL283201 | — | IC50 | = | 45.0 | nM | 7.35 |