Compound Detail
CHEMBL32079
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Basic Information
| ChEMBL ID | CHEMBL32079 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HVRIYPDAXABTLC-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
474.9
MW (Da)
4.46
ALogP
7
HBA
3
HBD
105.6
PSA (Ų)
0.26
QED
0
Ro5 Violations
12
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 8.77 | 8.77 | 1.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 1.7 | nM | 8.77 | Inhibition of phosphorylation of a polyglutamic acid/tyrosine random copolymer b... | 10753475 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10753475 | 10.1021/jm990482t | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine