Assay Detail
Binding
CHEMBL674063
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Binding affinity for [3H]raclopride-labeled dopamine receptor D2 in rat striatum
17
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Centrally acting serotonergic and dopaminergic agents. 2. Synthesis and structure-activity relationships of 2,3,3a,4,9,9a-hexahydro-1H-benz[f]indole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.16 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11066 | — | — | 2 | 8.70 |
| CHEMBL11363 | — | — | 2 | 8.52 |
| CHEMBL275689 | — | — | 2 | 7.96 |
| CHEMBL267557 | — | — | 1 | 7.33 |
| CHEMBL11771 | — | — | 1 | 6.93 |
| CHEMBL11294 | — | — | 1 | 6.37 |
| CHEMBL275057 | — | — | 1 | 6.33 |
| CHEMBL273601 | — | — | 1 | 6.13 |
| CHEMBL11388 | — | — | 1 | 6.06 |
| CHEMBL11065 | — | — | 1 | - |
| CHEMBL11170 | — | — | 1 | - |
| CHEMBL275008 | — | — | 1 | - |
| CHEMBL56 | 8-OH-DPAT | — | 1 | - |
| CHEMBL11880 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11066 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL11363 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL275689 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL11066 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL11363 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL267557 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL11771 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL275689 | — | Ki | = | 296.0 | nM | 6.53 |
| CHEMBL11294 | — | Ki | = | 429.0 | nM | 6.37 |
| CHEMBL275057 | — | Ki | = | 465.0 | nM | 6.33 |
| CHEMBL273601 | — | Ki | = | 748.0 | nM | 6.13 |
| CHEMBL11388 | — | Ki | = | 877.0 | nM | 6.06 |
| CHEMBL11880 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL56 | 8-OH-DPAT | Ki | > | 1000.0 | nM | - |
| CHEMBL275008 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL11170 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL11065 | — | Ki | > | 630.0 | nM | - |