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Assay Detail

CHEMBL674067

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards dopamine receptor D2 using [3H]-raclopride radioligand.
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(2) dopamine receptor (CHEMBL339)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist.
López-Rodríguez ML, Rosado ML, Benhamú B, Morcillo MJ, Sanz AM, Orensanz L, Beneitez ME, Fuentes JA, Manzanares J.
J Med Chem (1996) 39 : 4439 -4450
PubMed 8893838 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 50 6.66 7.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL8618 NAN-190 1 7.19
CHEMBL417709 1 7.04
CHEMBL42810 1 6.97
CHEMBL42644 1 6.89
CHEMBL290039 1 6.82
CHEMBL296713 1 6.61
CHEMBL46535 1 6.44
CHEMBL43332 1 6.38
CHEMBL296413 1 6.21
CHEMBL49 BUSPIRONE 4.0 1 6.07
CHEMBL46672 1 -
CHEMBL297887 1 -
CHEMBL298286 1 -
CHEMBL42881 1 -
CHEMBL296724 1 -
CHEMBL42396 1 -
CHEMBL41978 1 -
CHEMBL430567 1 -
CHEMBL290203 1 -
CHEMBL432495 1 -
CHEMBL42654 1 -
CHEMBL45253 1 -
CHEMBL46471 1 -
CHEMBL44876 1 -
CHEMBL46802 1 -
CHEMBL45007 1 -
CHEMBL46525 1 -
CHEMBL289784 1 -
CHEMBL295168 1 -
CHEMBL46377 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL8618 NAN-190 Ki = 64.0 nM 7.19
CHEMBL417709 Ki = 90.6 nM 7.04
CHEMBL42810 Ki = 107.0 nM 6.97
CHEMBL42644 Ki = 129.0 nM 6.89
CHEMBL290039 Ki = 151.0 nM 6.82
CHEMBL296713 Ki = 246.0 nM 6.61
CHEMBL46535 Ki = 361.0 nM 6.44
CHEMBL43332 Ki = 416.0 nM 6.38
CHEMBL296413 Ki = 615.0 nM 6.21
CHEMBL49 BUSPIRONE Ki = 852.0 nM 6.07
CHEMBL42219 Ki > 10000.0 nM -
CHEMBL47200 Ki > 1000.0 nM -
CHEMBL43992 Ki > 1000.0 nM -
CHEMBL46862 Ki > 10000.0 nM -
CHEMBL295527 Ki > 10000.0 nM -
CHEMBL47040 Ki > 1000.0 nM -
CHEMBL42706 Ki > 1000.0 nM -
CHEMBL297844 Ki > 10000.0 nM -
CHEMBL46470 Ki > 10000.0 nM -
CHEMBL291165 Ki > 1000.0 nM -
CHEMBL416984 Ki > 1000.0 nM -
CHEMBL46881 Ki > 1000.0 nM -
CHEMBL46651 Ki > 10000.0 nM -
CHEMBL46885 Ki > 1000.0 nM -
CHEMBL295244 Ki > 1000.0 nM -
CHEMBL46918 Ki > 1000.0 nM -
CHEMBL44786 Ki > 1000.0 nM -
CHEMBL289873 Ki > 1000.0 nM -
CHEMBL46677 Ki > 1000.0 nM -
CHEMBL42404 Ki > 1000.0 nM -
CHEMBL42654 Ki > 10000.0 nM -
CHEMBL46377 Ki > 10000.0 nM -
CHEMBL295168 Ki > 10000.0 nM -
CHEMBL289784 Ki > 10000.0 nM -
CHEMBL46525 Ki > 1000.0 nM -
CHEMBL45007 Ki > 1000.0 nM -
CHEMBL46802 Ki > 1000.0 nM -
CHEMBL44876 Ki > 1000.0 nM -
CHEMBL46471 Ki > 1000.0 nM -
CHEMBL45253 Ki > 1000.0 nM -
CHEMBL432495 Ki > 10000.0 nM -
CHEMBL46672 Ki > 10000.0 nM -
CHEMBL297887 Ki > 10000.0 nM -
CHEMBL298286 Ki > 10000.0 nM -
CHEMBL42881 Ki > 10000.0 nM -
CHEMBL296724 Ki > 1000.0 nM -
CHEMBL42396 Ki > 1000.0 nM -
CHEMBL41978 Ki > 1000.0 nM -
CHEMBL430567 Ki > 1000.0 nM -
CHEMBL290203 Ki > 1000.0 nM -