Assay Detail
Binding
CHEMBL674071
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit specific binding of [125I]- -ET-1 to rat A 10 cells which express endothelin A receptor
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | A10 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent and selective ET-A antagonists. 2. Discovery and evaluation of potent and water soluble N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 10.41 | 10.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112531 | — | — | 1 | 10.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112531 | — | IC50 | = | 0.039 | nM | 10.41 |