Assay Detail
Functional
CHEMBL674320
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Effective concentration required to inhibit Vaccinia virus-induced cytopathicity by 50% in E6SM cell lines
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | E6SM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.74 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL606446 | — | — | 1 | 5.72 |
| CHEMBL607985 | — | — | 1 | 4.31 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 4.19 |
| CHEMBL140440 | — | — | 1 | - |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL606446 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL607985 | — | EC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL140440 | — | EC50 | > | 250000.0 | nM | - |
| CHEMBL182 | GANCICLOVIR | EC50 | > | 100000.0 | nM | - |