Assay Detail
Binding
CHEMBL674428
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Binding affinity against Dopamine transporter using [125]RTI-55
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.94 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 8.43 |
| CHEMBL26320 | — | — | 1 | 8.43 |
| CHEMBL129193 | — | — | 1 | 7.72 |
| CHEMBL3084919 | — | — | 1 | 7.72 |
| CHEMBL3084920 | — | — | 1 | 7.55 |
| CHEMBL3084918 | — | — | 1 | 7.52 |
| CHEMBL126235 | — | — | 1 | 7.28 |
| CHEMBL130643 | — | — | 1 | 6.89 |
| CHEMBL1201203 | BENZTROPINE | 4.0 | 1 | 6.62 |
| CHEMBL3084921 | — | — | 1 | 6.57 |
| CHEMBL3084922 | — | — | 1 | 6.55 |
| CHEMBL339614 | — | — | 1 | 6.30 |
| CHEMBL415721 | — | — | 1 | 5.64 |
| CHEMBL127053 | — | — | 1 | 5.47 |
| CHEMBL126735 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL26320 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL129193 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL3084919 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL3084920 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL3084918 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL126235 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL130643 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL1201203 | BENZTROPINE | Ki | = | 237.0 | nM | 6.62 |
| CHEMBL3084921 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL3084922 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL339614 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL415721 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL127053 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL126735 | — | Ki | = | 3800.0 | nM | 5.42 |