Assay Detail
Binding
CHEMBL674514
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]ET1 from Endothelin B receptor of rat cerebellum
14
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebellum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design of C-terminal peptide antagonists of endothelin: structure-activity relationships of ET-[1621, D-His16]
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.07 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146155 | — | — | 1 | 7.52 |
| CHEMBL327350 | — | — | 1 | 7.46 |
| CHEMBL313984 | — | — | 1 | 7.30 |
| CHEMBL86814 | — | — | 2 | 6.85 |
| CHEMBL147908 | — | — | 1 | 5.89 |
| CHEMBL2370070 | — | — | 1 | 5.40 |
| CHEMBL315658 | — | — | 1 | 5.03 |
| CHEMBL289687 | — | — | 1 | 5.00 |
| CHEMBL273391 | — | — | 1 | 4.73 |
| CHEMBL87724 | — | — | 1 | - |
| CHEMBL312916 | — | — | 1 | - |
| CHEMBL330489 | — | — | 1 | - |
| CHEMBL432091 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146155 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL327350 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL313984 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL86814 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL147908 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL86814 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2370070 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL315658 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL289687 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL273391 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL87724 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL312916 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL330489 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL432091 | — | IC50 | > | 50000.0 | nM | - |