Assay Detail
Binding
CHEMBL674682
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against rat Dopamine receptor D2.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.64 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9669 | — | — | 1 | 7.19 |
| CHEMBL276156 | — | — | 1 | 6.96 |
| CHEMBL273923 | — | — | 1 | 6.84 |
| CHEMBL9452 | — | — | 1 | 6.61 |
| CHEMBL9870 | — | — | 1 | 6.42 |
| CHEMBL9467 | — | — | 1 | 6.35 |
| CHEMBL9921 | — | — | 1 | 6.08 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | 2.0 | 1 | - |
| CHEMBL9434 | PHENYLPIPERAZINE | — | 1 | - |
| CHEMBL9429 | — | — | 1 | - |
| CHEMBL275943 | — | — | 1 | - |
| CHEMBL9746 | — | — | 1 | - |
| CHEMBL269784 | — | — | 1 | - |
| CHEMBL266250 | — | — | 1 | - |
| CHEMBL267153 | — | — | 1 | - |
| CHEMBL9666 | — | — | 1 | - |
| CHEMBL269521 | MK-212 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9669 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL276156 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL273923 | — | Ki | = | 144.0 | nM | 6.84 |
| CHEMBL9452 | — | Ki | = | 244.0 | nM | 6.61 |
| CHEMBL9870 | — | Ki | = | 379.0 | nM | 6.42 |
| CHEMBL9467 | — | Ki | = | 449.0 | nM | 6.35 |
| CHEMBL9921 | — | Ki | = | 841.0 | nM | 6.08 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | Ki | > | 1000.0 | nM | - |
| CHEMBL9434 | PHENYLPIPERAZINE | Ki | > | 1000.0 | nM | - |
| CHEMBL9429 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL275943 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL9746 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL269784 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL266250 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL267153 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL9666 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL269521 | MK-212 | Ki | > | 1000.0 | nM | - |