Assay Detail
Functional
CHEMBL674826
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Evaluated for its ability to displace tritiated receptor ligand in rat striatal membranes [3H]ADTN, a dopamine agonist
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and dopaminergic activity of some 3-(1,2,3,6-tetrahydro-1-pyridylalkyl)indoles. A novel conformational model to explain structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 8.12 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431367 | ROXINDOLE | 2.0 | 1 | 9.06 |
| CHEMBL338710 | — | — | 1 | 8.80 |
| CHEMBL130659 | — | — | 1 | 8.74 |
| CHEMBL130502 | — | — | 1 | 8.60 |
| CHEMBL132446 | — | — | 1 | 8.51 |
| CHEMBL132270 | — | — | 1 | 8.40 |
| CHEMBL130614 | — | — | 1 | 8.37 |
| CHEMBL130327 | — | — | 1 | 8.36 |
| CHEMBL338849 | — | — | 1 | 8.27 |
| CHEMBL131841 | — | — | 1 | 7.92 |
| CHEMBL419957 | — | — | 1 | 7.89 |
| CHEMBL131356 | — | — | 1 | 7.82 |
| CHEMBL64344 | — | — | 1 | 7.82 |
| CHEMBL131711 | — | — | 1 | 7.68 |
| CHEMBL339954 | — | — | 1 | 7.39 |
| CHEMBL130501 | — | — | 1 | 7.34 |
| CHEMBL127609 | — | — | 1 | 7.09 |
| CHEMBL59335 | — | — | 1 | - |
| CHEMBL130605 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431367 | ROXINDOLE | Ki | = | 0.88 | nM | 9.06 |
| CHEMBL338710 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL130659 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL130502 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL132446 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL132270 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL130614 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL130327 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL338849 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL131841 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL419957 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL131356 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL64344 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL131711 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL339954 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL130501 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL127609 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL59335 | — | Ki | > | 100.0 | nM | - |
| CHEMBL130605 | — | Ki | > | 1000.0 | nM | - |