Assay Detail
Functional
CHEMBL674928
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concentration required to inhibit VSV-induced cytopathicity by 50% in E6SM cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | E6SM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Inactivation of S-adenosyl-L-homocysteine hydrolase and antiviral activity with 5',5',6',6'-tetradehydro-6'-deoxy-6'-halohomoadenosine analogues (4'-haloacetylene analogues derived from adenosine).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.49 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL608312 | — | — | 1 | 7.10 |
| CHEMBL608943 | — | — | 1 | 5.22 |
| CHEMBL608911 | — | — | 1 | 4.16 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL608312 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL608943 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL608911 | — | EC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 192000.0 | nM | - |