Assay Detail
Binding
CHEMBL674977
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Binding affinity against D-2 dopamine receptor in rat brain membranes using [3H](-)-sulpiride as radioligand.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and characterization of [125I]-N-(N-benzylpiperidin-4-yl)-4- iodobenzamide, a new sigma receptor radiopharmaceutical: high-affinity binding to MCF-7 breast tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.08 | 7.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL539938 | — | — | 1 | 7.61 |
| CHEMBL46326 | — | — | 1 | 7.20 |
| CHEMBL50112 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL539938 | — | Ki | = | 24.8 | nM | 7.61 |
| CHEMBL46326 | — | Ki | = | 63.4 | nM | 7.20 |
| CHEMBL50112 | — | Ki | = | 382.0 | nM | 6.42 |