Assay Detail
Binding
CHEMBL675094
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory against radioligand [3H]spiperone binding to rat striatal Dopamine receptor D2
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.90 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL479 | THIORIDAZINE | 4.0 | 1 | 7.22 |
| CHEMBL140831 | — | — | 1 | 6.70 |
| CHEMBL141455 | — | — | 1 | 6.40 |
| CHEMBL334934 | — | — | 1 | 6.38 |
| CHEMBL140656 | — | — | 1 | 6.31 |
| CHEMBL140872 | — | — | 1 | 6.17 |
| CHEMBL137870 | — | — | 1 | 6.09 |
| CHEMBL138186 | — | — | 1 | 6.03 |
| CHEMBL335348 | — | — | 1 | 5.86 |
| CHEMBL342484 | — | — | 1 | 5.77 |
| CHEMBL443482 | — | — | 1 | 5.73 |
| CHEMBL141226 | — | — | 1 | 5.73 |
| CHEMBL141912 | — | — | 1 | 5.67 |
| CHEMBL141922 | — | — | 1 | 5.66 |
| CHEMBL141523 | — | — | 1 | 5.43 |
| CHEMBL141854 | — | — | 1 | 5.41 |
| CHEMBL139595 | — | — | 1 | 5.25 |
| CHEMBL60859 | BMY-14802 | — | 1 | 5.19 |
| CHEMBL344577 | — | — | 1 | 5.06 |
| CHEMBL140712 | — | — | 1 | - |
| CHEMBL140833 | — | — | 1 | - |
| CHEMBL137967 | — | — | 1 | - |
| CHEMBL140650 | — | — | 1 | - |
| CHEMBL141670 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL479 | THIORIDAZINE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL140831 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL141455 | — | IC50 | = | 396.0 | nM | 6.40 |
| CHEMBL334934 | — | IC50 | = | 415.0 | nM | 6.38 |
| CHEMBL140656 | — | IC50 | = | 494.0 | nM | 6.31 |
| CHEMBL140872 | — | IC50 | = | 679.0 | nM | 6.17 |
| CHEMBL137870 | — | IC50 | = | 817.0 | nM | 6.09 |
| CHEMBL138186 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL335348 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL342484 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL443482 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL141226 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL141912 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL141922 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL141523 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL141854 | — | IC50 | = | 3940.0 | nM | 5.41 |
| CHEMBL139595 | — | IC50 | = | 5660.0 | nM | 5.25 |
| CHEMBL60859 | BMY-14802 | IC50 | = | 6430.0 | nM | 5.19 |
| CHEMBL344577 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL140712 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL140833 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL137967 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL140650 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL141670 | — | IC50 | > | 1000.0 | nM | - |